It is essential for cleanroom contamination control to adopt the best working practices combined with an effective disinfectant and cleaning regime, and correct disinfectant selection is key to that success. 

Why are disinfectants important?

Without suitable disinfectants, even the most high-tech cleanrooms with robust hygiene procedures and working practices may eventually fail. Disinfectants are a diverse group of chemicals that reduce the number of micro-organisms present within any given area. Disinfectants vary in their spectrum of activity, modes of action and efficacy. For example, some disinfectants are effective against vegetative Gram-positive and Gram-negative micro-organisms only, while some are effective against fungi.

Choosing a disinfectant

The following list gives some key attributes to consider when choosing a disinfectant:

  • Ensure a wide spectrum of activity 
  • Is there a requirement for sporicidal agent? 
  • Does it have rapidity in action? Less than 10 minutes contact time is ideal
  • Ensure it has a different mode of action 
  • Prior to disinfection it is essential that dirt and soil is removed. This can be achieved using a detergent. 
  • Be aware that some disinfectants are not compatible with residues left behind by detergents
  • Understand that disinfectants leave residue
  • Disinfectants are not compatible with all surfaces
  • Understand the most suitable product presentation – ready-to-use or concentrate formulations, sprays or bottles and wiping
  • Supply and product costs 
  • Are the biocides registered to the Biocide Product Regulation (BPR).

Disinfection validation 

A sterile disinfectant should be selected that demonstrates performance against the following standards:

  • EN1276 – Chemical Disinfectants
  • Bacterial Activity Test EN1650 – Quantitative Suspension Test for the Evaluation of Fungicidal Activity of Chemical Disinfectants 
  • EN13697 – Quantitative Surface Test for the Evaluation of Bactericidal or Fungicidal Activity
  • EN13704 – Quantitative Suspension Test for the Evaluation of Sporicidal Activity of Chemical Disinfectants.

Selecting the right rotation

Rotation of disinfectants is a critical consideration when designing cleaning regimes. Although not clearly defined by regulatory authorities, the rotation of disinfectants are certainly a regulatory expectation and has been for many years. 

Key points are:

  • Assess the operating conditions 
  • Understand actual microbial data 
  • Always rotate the base chemical 
  • Always incorporate sporicides in rotation
  • Start with higher requirements, assess microbial data for a set period and realign cleaning requirements after evidence of successful periods of control.

Understanding and assessing residues 

Wherever biocides are used then residue will exist. The amount of residual biocide remaining on a surface is important to understand so that effective removal methods can be adopted.

Key points addressing residue are:

  • Select a biocide with a low
  • concentration, but high efficacy
  • Regularly remove residue with a
  • detergent before and/or after using the biocide
  • Alcohol can be used to remove residues after the planned cleaning activities
  • Highly purified water or WFI can be used to remove residues after the planned cleaning activities
  • Ensure that the wet contact time is observed
  • Always ensure that surfaces are dry prior to starting cleanroom activities
Spray or wipe?

Micro-organisms that are exposed to the disinfectants for the recommended contact time will be killed. Redditch Medical recently studied microbial activity assessing wiping performance in real practice condition following the guidance of EN16615. This study demonstrates contamination control can be improved by spraying and wiping surfaces to mechanically lift and remove surface contaminants.

InSpec is designed to offer to complete cleanroom contamination control. Detergents, sporicides, alcohols and aqueous biocides Our technical team can assist with all cleanroom contamination control requirements, designing working practices and making recommendations to meet the unique needs of every cleanroom.

Controlling any cleanroom is a fine balance; just like choosing a disinfectant, it is a balance between safety, modes of action, efficacy, contact times, corrosion, residue, shelf-life and in-use shelf-life, not to mention the covenience of cost 

As cleanroom users, the designers behind InSpec understand regulators’ expectations – including robust validation programmes demonstrating reasonedselection, challenge of site isolates and in-use efficacy that keeps the cleanroom micro-organisms in control. Sporicidal wipes and mops are somewhat rare in the cleanroom industry. Our contamination control division recently developed an innovative burstable pouch system now available in the InSpec range as a wipe or mop system. 


This unique concept preserves the integrity and efficacy of both the physical wipes and the sporicide or biocide solution until the pouch is activated at the point of use.

Covenient to handle

The impregnated wipes are sterile and convenient to handle; no added complications, such as mixing or waiting, are required by the operator. Packs are designed for session use and can be scaled to individual user needs. This ensures that there is no issue to product sterility and integrity exceeding more than one days use.

All InSpec solutions comply with EU GMP and CLP standards and are fully validated by independent bodies in industry and academia. Redditch Medical is supporting all products through the Biocide Product Regulation. Selecting a disinfectant can be time-consuming enough, therefore it is imperative that all end users are aware of this registration process. Some biocides must be registered as early as this year. Redditch Medical products are Article 95 registered and programmes are in place to ensure registration according to BPR timings.

Supply issues with disinfectants can shut down a cleanroom. Choose products that are available off-the-shelf and can be despatched the same day. Concurrent planning ensures every step of production considers individual customer needs. With modern cleanroom operations, service performance is as critical as efficacy performance.


As Strong As InSpec OX

As Strong As InSpec OX

InSpec’s very own OX is one of the most powerful sporicides available for hard surfaces and cleanroom use.

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InSpec Burstable Pouch Wipes

InSpec Burstable Pouch Wipes

Sterile biocidal and sporicidal session wipes. Maximum convenience via wipe format, with the maxiumum power of InSpec rotationals: OX, HA, AN, QT.

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