1. Disinfectants - why? 

Without suitable disinfectants, even the most hi-tech cleanrooms with robust hygiene procedures and working practices may eventually fail.

A disinfectant is a diverse group of chemicals that reduce the number of micro-organisms present within any given area.

Disinfectants vary in their spectrum of activity, modes of action and efficacy. The spectrum of activity varies with some disinfectants being effective against vegetative gram-positive as gram-negative micro-organisms only, whilst some are effective against fungi.

2. Should i spray or wipe?

Micro-organisms that are exposed to the disinfectants for the recommended contact time will be killed. Redditch Medical recently studied microbial activity assessing wiping performance in real practice conditions following the guidance of EN16615. This study demonstrates contamination control can be improved by spraying and wiping surfaces to mechanically lift and remove surface contaminants.

3. What are rotational disinfectants?

Rotation of disinfectants is a critical consideration when designing cleaning regimes. Although not clearly defined by regulatory authorities, the rotation of disinfectants is certainly a regulatory expectation and has been for many years.

The fundamental purpose of disinfectant rotation is to prevent selection for resistant organisms, not to prevent organisms becoming resistant to disinfectants as widely believed. For this reason you must rotate the biocide ensuring that the base chemicals are different, for example a quaternary ammonium rotated with diamine. A rotation program should include chemistries that control a wide variety of organisms and which mitigate damage to cleanroom surfaces.